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Abstract Protein language models (pLMs) have been widely adopted for various protein and peptide-related downstream tasks and demonstrated promising performance. However, short peptides are significantly underrepresented in commonly used pLM training datasets. For example, only 2.8% of sequences in the UniProt Reference Cluster (UniRef) contain fewer than 50 residues, which potentially limits the effectiveness of pLMs for peptide-specific applications. Here, we present PepBERT, a lightweight and efficient peptide language model specifically designed for encoding peptide sequences. Two versions of the model—PepBERT-large (4.9 million parameters) and PepBERT-small (1.86 million parameters)—were pretrained from scratch using four custom peptide datasets and evaluated on nine peptide-related downstream prediction tasks. Both PepBERT models achieved performance superior to or comparable to the benchmark model, ESM-2 with 7.5 million parameters, on 8 out of 9 datasets. Overall, PepBERT provides a compact yet effective solution for generating high-quality peptide representations for downstream applications. By enabling more accurate representation and prediction of bioactive peptides, PepBERT can accelerate the discovery of food-derived bioactive peptides with health-promoting properties, supporting the development of sustainable functional foods and value-added utilization of food processing by-products. The datasets, source codes, pretrained models, and tutorials for the usage of PepBERT are available athttps://github.com/dzjxzyd/PepBERT.more » « lessFree, publicly-accessible full text available April 14, 2026
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Free, publicly-accessible full text available March 24, 2026
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As distributed energy resources (DERs) are widely deployed, DC packetized power microgrids have been considered as a promising solution to incorporate DERs effectively and steadily. In this paper, we consider a DC packetized power microgrid, where the energy is dispatched in the form of power packets with the assist of a power router. However, the benefits of the microgrid can only be realized when energy subscribers (ESs) equipped with DERs actively participate in the energy market. Therefore, peer-to-peer (P2P) energy trading is necessary in the DC packetized power microgrid to encourage the usage of DERs. Different from P2P energy trading in AC microgrids, the dispatching capability of the router needs to be considered in DC microgrids, which will complicate the trading problem. To tackle this challenge, we formulate the P2P trading problem as an auction game, in which the demander ESs submit bids to compete for power packets, and a controller decides the energy allocation and power packet scheduling. Analysis of the proposed scheme is provided, and its effectiveness is validated through simulation.more » « less
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